Current Issue : January - March Volume : 2019 Issue Number : 1 Articles : 6 Articles
This article aims to provide detailed information on Malaysian plants used for treating inflammation. An extensive search on\nelectronic databases including PubMed, Google Scholar, Scopus, and ScienceDirect and conference papers was done to find\nrelevant articles on anti-inflammatory activity of Malaysian medicinal plants. The keyword search terms used were â??inflammation,â?\nâ??Malaysia,â? â??medicinal plants,â? â??mechanisms,â? â??in vitro,â? and â??in vivo.â? As a result, 96 articles on anti-inflammatory\nactivity of Malaysian medicinal plants were found and further reviewed. Forty-six (46) plants (in vitro) and 30 plants (in vivo) have\nbeen identified to possess anti-inflammatory activity where two plants, Melicope ptelefolia (Tenggek burung) and Portulaca\noleracea (Gelang pasir), were reported to have the strongest anti-inflammatory activity of more than 90% at a concentration of\n250 ... It was showed that the activity was mainly due to the occurrence of diverse naturally occurring phytochemicals from\ndiverse groups such as flavonoids, coumarins, alkaloids, steroids, benzophenone, triterpenoids, curcuminoids, and cinnamic acid.\nHence, this current review is a detailed discussion on the potential of Malaysian medicinal plants as an anti-inflammatory agent\nfrom the previous studies. However, further investigation on the possible underlying mechanisms and isolation of active\ncompounds still remains to be investigated....
This studyâ??s objective was to evaluate the rescued traditional knowledge about the\nchiricaspi (Brunfelsia grandiflora s.l.), obtained in an isolated Canelo-Kichwa Amazonian community\nin the Pastaza province (Ecuador). This approach demonstrates well the value of biodiversity\nconservation in an endangered ecoregion. The authors describe the ancestral practices that remain in\nforce today. They validated them through bibliographic revisions in data megabases, which presented\nactivity and chemical components. The authors also propose possible routes for the development of\nnew bioproducts based on the plant. In silico research about new drug design based on traditional\nknowledge about this species can produce significant progress in specific areas of childbirth,\nanesthesiology, and neurology....
The leaves of Aerva lanata are one of the indigenous medicinal plants used in the management of diabetes mellitus and its\nassociated complications in Africa. However, its effect on the activities of diabetes-related enzymes has not been investigated.\nThis study evaluated the in vitro inhibitory effects of different extracts of the A. lanata leaf on the activities of diabetes-related\nenzymes .. and chemically induced free radicals. Aqueous, ethanol, and hydroethanol extracts\nof A. lanata leaves were subjected to a standard enzyme inhibition assay followed by determination of modes of inhibition\nof the enzymes. The antioxidant activities of the extracts were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and\n2,2-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). The results obtained showed that the hydroethanol extract\nof the A. lanata leaf optimally inhibited both ..amylase (IC50: 2.42 mg/mL) and .. glucosidase (IC50: 0.23 mg/mL). The\nLineweaver-Burk plot revealed that the mode of inhibition of both enzymes by the hydroethanol extract was uncompetitive.\nHowever, the hydroethanol and aqueous extracts displayed the best DPPH and ABTS radical-scavenging ability, respectively.\nIt can be concluded that the A. lanata extract inhibited the activities of both .. amylase and .. glucosidase uncompetitively,\nwhich may be attributed to its free radical-scavenging properties and rich phenolic composition....
Objectives of the research was to investigate macroscopic, microscopic, qualitative phytochemical and pharmacognostic parameters of Solanum trilobatum (Tuduvalai) leaves, it is one of the important medicinal plants, more commonly available in Southern India and has been used in herbal medicine to treat various diseases like respiratory problems, bronchial asthma and tuberculosis. The plant is also used in preparation of variety of indigenous medicine. Macroscopic, microscopic, qualitative phytochemical analysis, extractive values in petroleum ether, chloroform, methanol and DMSO of the leaves were done. Macroscopic and microscopic study showed distinct morphological characteristics in the leaves. Phytochemical analysis of leaves powder revealed that alkaloids, carbohydrates, proteins, amino acids, phytosterol, tannin, glycosides, saponins, flavonoids and terpenoids were present in leaf extracts. Pharmacognostic study of leaves were helpful to identification and ensure quality and purity standards of tuduvalai (Solanum trilobatum). The qualitative phytochemical screening is helpful in further pharmacological approaches....
Oral and skin infections contribute significantly to the global health challenges responsible for the current trend of increased\nmorbidity and premature death. The purpose of this study was to document medicinal plants used in the management of oral\nand skin infections in Ebem-Ohafia Local Government Area (LGA), Abia State, and to characterize the in vitro antioxidant and\nantibacterial activity.The thin layer chromatography (TLC) profiling of ten of the selected folklore medicine was carried out using\na various solvent system of different polarity index. The antioxidant capacity of the plant extracts was evaluated using chemicalbased\nmethods, and its antibacterial effect was investigated using disc diffusion and microdilution methods. Sixty-one plant species\nbelonging to 26 families were discovered, and the most frequently cited species are Euphorbiaceae (18.03%), Fabaceae (11.47%),\nand Asteraceae (11.47%). All the plant extracts showed a promising free radical scavenging activity and efficient ferric reducing\nantioxidant power in a concentration-dependentmanner possibly due to their richness in polyphenol with TLC profiling showing\nmaximum three bands of phytochemicals. Also, the plant extracts exhibited a mild to weak antibacterial activity against our panel\nof bacterial strains having MIC values ranging from 256 to > 512 ..mL reflected in their zone of inhibition at 10 disc. The\ndata obtained for Breynia nivosa (BN), Eleusine indica (EI), Cassia alata (CA), Chromolaena odorata (CO), and Acalypha hispida\n(AH) extracts substantiate the traditional use of these herbal remedies in the region and open the possibility for the development\nof cheaper and affordable drugs in the treatment of oral and skin infections. Further studies are needed to identify active ingredient\nwith strong antibacterial and antioxidant capacities along with their molecular mechanisms....
One of the possible ways to challenge selenium (Se) and iodine (I) deficiency in human\nbeings is the joint biofortification of plants with these elements. Though the relationship between\nSe and I is highly pronounced in mammals, little is known about their interactions in plants where\nSe and I are considered not to be essential. Peculiarities of Se and I assimilation by a natural Se\naccumulator, such as Brassica juncea L., cultivar Volnushka, were assessed upon joint and separate\nplant foliar supply with sodium selenate ..... and potassium iodide ..... in two\ncrop seasons (spring, summer). Conversely to the individual application of Se and I, their joint\nsupply did not stimulate plant growth. Separate use of sodium selenate enhanced I accumulation\nby 2.64 times, while biofortification with I increased the Se content in plant leaves by 4.3 times; this\nphenomenon was also associated with significant increase of total soluble solids and ascorbic acid\ncontent in leaves. The joint supply of Se and I did not affect the mentioned parameters. Both joint\nand separate application of Se and I led to synergism between these elements in: inhibiting nitrate\naccumulation; stimulating flavonoids biosynthesis ..... times compared to control plants) as well as\nAl and B accumulation; decreasing Cd and Sr concentrations. Plant biofortification with I increased\nthe content of Mn and decreased K and Li. The consumption of 100 g Brassica juncea leaves provided\n100% of the adequate human requirement of Se and 15.5% of I....
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